AffiPCR® Influenza A H5 H7 H9 Typing FRT

Target Disease Type: Respiratory Infections

Specific Application: Influenza

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Influenza A H5 H7 H9 Typing FRT (CE) V47-50FRT DataSheet

INTRODUCTION

Avian influenza is an infectious disease of birds caused by type A strains of the influenza virus. The disease, which was first identified in Italy more than 100 years ago, occurs worldwide. All birds are thought to be susceptible to infection with avian influenza, though some species are more resistant to infection than others. Infection causes a wide spectrum of symptoms in birds, ranging from mild illness to a highly contagious and rapidly fatal disease resulting in severe epidemics. The latter is known as “highly pathogenic avian influenza”. This form is characterized by sudden onset, severe illness, and rapid death, with a mortality that can approach 100%. Fifteen subtypes of influenza virus are known to infect birds, thus providing an extensive reservoir of influenza viruses potentially circulating in bird populations. To date, all outbreaks of the highly pathogenic form have been caused by influenza A viruses of subtypes H5, H7 and H9.

INTENDED USE

Influenza A H5 H7 H9 Typing FRT is Real-Time amplification test for the qualitative detection of Influenza A virus H5, H7 and H9 subtypes.

PRINCIPLE OF ASSAY

Influenza A H5 H7 H9 Typing FRT Test is based on four major processes: isolation of Influenza A virus RNA from specimens, reverse transcription of the RNA, Real Time amplification of the cDNA Of Influenza A virus with subsequent identification of subtypes Н5, H7 and H9. Real-time RT-PCR test for influenza A virus with “Influenza A Real-TM” (Sacace, ref. TVET46-50FRT) is recommended as a screening test for all suspected cases of influenza A virus. Influenza A H5 H7 H9 Typing FRT kit must be used for H5, H7 and H9 genotyping.